Stayton Lab, Department of Bioengineering
My project with the Stayton lab during my sophomore year yielded an ACS Nano publication: pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides. I demonstrated that the nanocarriers we developed facilitate gene knockdown in dendritic cells and elevated IgG titres in murine models, which attests to the therapeutic potential of our tunable and multimodal drug delivery platform.
Atkins Lab, Department of Medicinal Chemistry
Amgen Scholars Program: Quantification of Quantum Dots in Solution using Surface Plasmon Resonance and Analytical Ultracentrifugation
Maturation of Nanodiscs to High Density Lipoprotein-Like Particles via Lecithin Cholesterol Acyl Transferase
During my senior year with Professor William Atkins, I worked on another drug delivery project for my thesis, which you will find below the poster. I aimed to create HDL-like particles with a narrow size distribution for future use in drug delivery. I made the particles from nanodiscs, which are synthetic membrane models with low polydispersity. I demonstrated evidence of formation of the particles and performed further characterization to gain insight on their size and shape. I also used this as an honors experiential learning project.